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It was used to strengthen blood circulation of coronary artery, arrhythmia and hyperlipidemia. The main objective of this paper is to evaluate lipid-lowering and antioxidant activities of extract and effective fraction of JZN by using in vitro experiments on hyperlipidemic rats. Moreover, in vivo experiments on cells were performed to investigate lipid-lowering and antioxidant activities of effective fraction and active constituents of JZN.

Wistar rats with high fat diet-induced hyperlipidemia were used as in vitro models to study biological effects of lipid-lowering and antioxidant activities of extract and effective fraction of JZN.

Furthermore, oxidized low-density lipoprotein Ox-LDL injured human umbilical vein endothelial cell HUVEC model was employed as in vivo experiment to study lipid-lowering and antioxidant effects of effective fraction and active constituents of JZN.

Using human hepatoma cell line Bel, reverse transcription polymerase chain reaction RT-PCR technology was performed to investigate cholesterol metabolism effects of effective fraction and active constituents of JZN.

Expressions of low density lipoprotein receptor LDL.